Tirzepatide for Weight Loss: How Does It Work?

If you’ve tried everything and still feel like real weight loss is out of reach, you’re not alone. For some, that’s where medications like tirzepatide can make a difference. Marketed under the brand names Mounjaro and Zepbound, tirzepatide for weight loss has become increasingly popular among individuals who haven’t found success with other methods.

At Victory Men’s Health, we offer both semaglutide and tirzepatide as tools for weight loss. While many of our patients have heard of semaglutide, few know what tirzepatide is and how it differs from other weight loss medications. In this blog post, we’re sharing everything you need to know about tirzepatide so you can make more informed decisions about your health. 

What is Tirzepatide?

Tirzepatide is a dual-action medication that was originally developed to manage Type 2 diabetes. It was designed to help regulate blood sugar by targeting two hormone receptors at once: GLP-1 and GIP. Sold under the brand name Mounjaro for diabetes or Zepbound for weight loss, tirzepatide’s dual approach has also made it a fantastic tool for weight loss. 

Unlike semaglutide, (marketed under brand names like Ozempic and Wegovy), which only activates GLP-1 receptors, tirzepatide also engages GIP (glucose-dependent insulinotropic polypeptide) receptors. By targeting GIP, the medication’s ability to help with appetite suppression and metabolic regulation is even more powerful. 

Tirzepatide’s dual-action capability means it can be more effective for some patients in achieving and maintaining weight loss—often with fewer side effects.

How Does It Work?

Tirzepatide works by mimicking the natural hormones GLP-1 and GIP, which regulate blood sugar and appetite. Here’s how each hormone plays a role.

• GLP-1: This hormone curbs hunger by slowing down the rate at which your stomach empties food, making you feel fuller for longer. It also helps reduce blood sugar levels by enhancing insulin sensitivity and reducing sugar production in the liver.

• GIP: By activating the GIP receptor, tirzepatide amplifies the effects of insulin, especially after meals, and further contributes to the feeling of fullness. The combination of these two hormones helps lower calorie intake and minimizes the likelihood of fat storage.

Tirzepatide vs. Semaglutide: What’s the Difference?

At Victory Men’s Health, we offer both tirzepatide (Mounjaro) and semaglutide (Ozempic or Wegovy) to help our patients reach their weight loss goals. Both can be effective, but there are some key differences to consider before deciding which one is right for you. 

• Dual-Action Mechanism: Tirzepatide activates both GLP-1 and GIP receptors, while semaglutide targets only GLP-1. This dual action in tirzepatide can lead to greater appetite suppression.

• Weight Loss Effectiveness: Studies show tirzepatide users see an average weight reduction of about 20% of body weight, compared to around 15% with semaglutide.

• Ideal Fit: Semaglutide works well for those who respond effectively to GLP-1 alone, while tirzepatide may be better for individuals who need additional support to control their appetite and blood sugar.

Our team will help you determine which option aligns best with your needs and health goals for a personalized, effective weight loss treatment plan. On an episode of the Women Want Strong Men podcast, nurse practitioner Anna Griffith shared her expert insights on semaglutide and tirzepatide. Check it out below and keep reading to learn more about tirzepatide.

Benefits of Tirzepatide for Weight Loss

Weight loss isn’t just about hitting a lower number on the scale—it’s about improving your overall health so you can feel stronger and live better. For many men, extra weight comes with increased risks of cardiovascular disease and other health issues. Tirzepatide addresses these risk factors for benefits that go beyond your physical appearance.

At Victory Men’s Health, we’re particularly fond of tirzepatide for its ability to reduce visceral fat—the belly fat that wraps around your organs and contributes to serious health issues. By targeting both GLP-1 and GIP hormones, this weight loss medication helps bring balance to your body in a way that benefits your energy levels, heart health, and metabolic function.

Here’s a closer look at the key benefits of tirzepatide: 

• Improved Cardiovascular Health – Studies have shown that GLP-1 medications can reduce the risk of cardiovascular issues. For men, weight loss plus cardiovascular support means a lower risk of high blood pressure, heart disease, and other age-related conditions.

• Better Cholesterol and Blood Sugar Levels – Tirzepatide helps stabilize blood sugar and can positively impact cholesterol levels, which is essential for reducing the risk of diabetes, metabolic syndrome, and other health complications.

• Reduced Visceral Fat – This medication particularly helps in reducing visceral fat—the type that surrounds organs like the liver. Visceral fat is associated with higher risks of heart disease and other metabolic disorders, making its reduction a big win for long-term health.

What are the Side Effects of Tirzepatide?

Like any medication, tirzepatide comes with potential side effects, although they’re generally mild and manageable. Here’s what to watch for and some practical tips to minimize discomfort.

• Nausea: Nausea is common among tirzepatide users, especially at the start or after increasing the dose. To manage this side effect, try eating smaller meals throughout the day, avoid heavy or fried foods, drink plenty of water, and consider natural remedies like ginger lozenges or tea.

• Constipation: Some people experience constipation with tirzepatide. Staying hydrated (aim for half your body weight in ounces daily) and increasing your fiber intake from whole foods like vegetables and fruits can help. Adding gentle physical activity, like walking, can also improve digestion.

• Muscle Loss: When losing weight, it’s not uncommon to lose muscle alongside fat. To combat this, we recommend a balanced diet with adequate protein (0.7–1 gram of protein per ideal pound of body weight) and strength training exercises. Monitoring not only weight, but muscle mass and body fat percentage, is key to ensuring muscle loss is minimal to none. 

Most of our patients find that these side effects subside as their body adjusts to the weight loss medication. If issues persist, your healthcare provider may recommend adjusting the dosage or using other personalized strategies to alleviate symptoms.

Who Should Consider Tirzepatide for Weight Loss?

Tirzepatide may be right for you if you’re looking for an effective weight-loss solution that offers metabolic and cardiovascular benefits. Ideal candidates include individuals who:

• Have a BMI or body fat percentage in the overweight or obese range and are struggling to lose weight through diet and exercise alone.
• Are managing or at risk for metabolic health issues such as prediabetes or Type 2 diabetes.
• Have tried other weight loss medications or programs without the desired results.

At Victory Men’s Health, we take a personalized approach to weight loss, evaluating each patient’s health profile, goals, and lifestyle before recommending tirzepatide or any medication.

Questions Our Patients Ask About Tirzepatide

How Quickly Do You Lose Weight on Tirzepatide?

Weight loss can vary, but many patients start seeing noticeable results within the first few weeks. Progress generally continues as your body adjusts to the medication and any necessary lifestyle changes.

How Can I Lose More Weight on Tirzepatide?

Combining tirzepatide with a high-protein, low-processed food diet and incorporating strength training can help you maximize weight loss without losing muscle. 

What Should You Avoid While Taking Tirzepatide?

Avoid foods that may cause nausea, like fried or overly sugary items. Excessive alcohol consumption may also trigger side effects, so it’s best to limit intake while on this medication.

Will I Gain Weight After Stopping Tirzepatide?

Some weight regain can happen if you don’t maintain lifestyle changes. However, continuing healthy habits like mindful eating, regular exercise, and a balanced diet can help you sustain your progress long after you’ve stopped tirzepatide. 

How is Tirzepatide Different from Semaglutide?

Tirzepatide acts on both GLP-1 and GIP receptors, while semaglutide only targets GLP-1. This dual action often makes tirzepatide more effective for weight loss. 

Can You Take Other Medications with Tirzepatide?

It depends on the medication. Our providers carefully review each patient’s medication list to prevent any adverse interactions and ensure a safe treatment plan.

Start Your Weight Loss Journey with Victory Men’s Health

Tirzepatide offers an effective, science-backed way to tackle weight loss and improve overall health. Unlike other weight loss solutions, this medication’s dual-hormone approach makes it uniquely effective at curbing appetite, stabilizing blood sugar, and reducing visceral fat. 

If you’re interested in exploring tirzepatide as part of your weight loss journey, we’re here to help. Our team of experts are committed to personalized care, offering in-person and telehealth consultations to make your journey as convenient as possible. 

Contact us today to book a consultation and determine if tirzepatide is right for you.